Nov 1, 2009: GENDIA now offers a next-generation sequencing  platform for the molecular diagnosis of Familial Arrythmia.
This platform is directly sequencing single DNA molecules with the Helicos' True Single Molecule Sequencing (tSMS)™ technology.
The platform detects mutations in:

> 75% of Long QT syndrome – Brugada syndrome
> 50% Arrhythmogenic Right Ventricular Dysplasia (ARVD) / Cardiomyopathy
> 50% of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
> 7% Atrial Fibrillation

with sequencing of the following 24 genes:

• ANK2 encoding Ankyrin-B
• CACNA1C encoding Calcium channel, L type, alpha 1
• CACNB2 encoding Calcium channel, voltage-dependent, beta 2
• CASQ2 encoding Calsequestrin
• CAV3 encoding Caveolin 3
• DSC2 encoding Desmocollin-2
• DSG2 encoding Desmoglein-2
• DSP encoding Desmoplain
• GPD1L encoding Glycerol-3-phosphate dehydrogenase 1-like
• JUP encoding Junction plakoglobin
• KCNE1 encoding Voltage-gated potassium channel, Isk related, member 1
• KCNE2 encoding Voltage-gated potassium channel, Isk related, member 2
• KCNH2 encoding Potassium channel, voltage-gated, H2
• KCNJ2 encoding Inwardly rectifying potassium channel
• KCNQ1 encoding KQT-like voltage-gated potassium channel 1
• NPPA encoding Natriuretic peptide precursor a
• PKP2 encoding Plakophilin-2
• PLN encoding Phospholamban
• RYR2 encoding Ryanodine receptor 2
• SCN1B encoding Sodium channel, voltage-gated, type 1B
• SCN4B encoding Sodium channel, voltage-gated, type 4B
• SCN5A encoding Sodium channel, voltage-gated, type 5A
• TGFB3 encoding Transforming growth factor, beta 3
• TMEM43 encoding Transmembrane protein 43

The price for the analysis of the 24 genes in a single sample is 2000 Euro.
Once a disease-causing mutation is identified, family members can be screened for that mutation at 250 Euro.
The turnaround time of the test is 3 months.

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